Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis

Daster, Silvio and Eppenberger-Castori, Serenella and Hirt, Christian and Soysal, Savas D. and Delko, Tarik and Nebiker, Christian A. and Weixler, Benjamin and Amicarella, Francesca and Iezzi, Giandomenica and Governa, Valeria and Padovan, Elisabetta and Mele, Valentina and Sconocchia, Giuseppe and Heberer, Michael and Terracciano, Luigi and Kettelhack, Christoph and Oertli, Daniel and Spagnoli, Giulio C. and von Holzen, Urs and Tornillo, Luigi and Droeser, Raoul A.. (2015) Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis. Oncoimmunology, 4 (12). e1050574.

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Official URL: https://edoc.unibas.ch/61936/

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Colorectal cancer (CRC) infiltration by cells expressing myeloperoxidase (MPO) or CD8 positive T lymphocytes has been shown to be independently associated with favorable prognosis. We explored the relationship occurring between CD8+ and MPO+ cell CRC infiltration, its impact on clinical-pathological features and its prognostic significance in a tissue microarray (TMA) including 1,162 CRC. We observed that CRC showing high MPO+ cell infiltration are characterized by a prognosis as favorable as that of cancers with high CD8+ T cell infiltration. However, MPO+ and CD8+ CRC infiltrating cells did not synergize in determining a more favorable outcome, as compared with cancers showing MPOhigh/CD8low or MPOlow/CD8high infiltrates. Most importantly, we identified a subgroup of CRC with MPOlow/CD8low tumor infiltration characterized by a particularly severe prognosis. Intriguingly, although MPO+ and CD8+ cells did not co-localize in CRC infiltrates, an increased expression of TIA-1 and granzyme-B was detectable in T cells infiltrating CRC with high MPO+ cell density.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunotherapy (Iezzi)
UniBasel Contributors:Iezzi, Giandomenica
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2162-4011 (Print) 2162-4011 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Nov 2018 09:42
Deposited On:03 Nov 2018 09:42

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