Dynamic spatio-temporal contribution of single beta5t+ cortical epithelial precursors to the thymus medulla

Mayer, C. E. and Zuklys, S. and Zhanybekova, S. and Ohigashi, I. and Teh, H. Y. and Sansom, S. N. and Shikama-Dorn, N. and Hafen, K. and Macaulay, I. C. and Deadman, M. E. and Ponting, C. P. and Takahama, Y. and Hollander, G. A.. (2016) Dynamic spatio-temporal contribution of single beta5t+ cortical epithelial precursors to the thymus medulla. Eur J Immunol, 46 (4). pp. 846-856.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61926/

Downloads: Statistics Overview


Intrathymic T-cell development is critically dependent on cortical and medullary thymic epithelial cells (TECs). Both epithelial subsets originate during early thymus organogenesis from progenitor cells that express the thymoproteasome subunit beta5t, a typical feature of cortical TECs. Using in vivo lineage fate mapping, we demonstrate in mice that beta5t(+) TEC progenitors give rise to the medullary TEC compartment early in life but significantly limit their contribution once the medulla has completely formed. Lineage-tracing studies at single cell resolution demonstrate for young mice that the postnatal medulla is expanded from individual beta5t(+) cortical progenitors located at the cortico-medullary junction. These results therefore not only define a developmental window during which the expansion of medulla is efficiently enabled by progenitors resident in the thymic cortex, but also reveal the spatio-temporal dynamics that control the growth of the thymic medulla.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Pediatric Immunology (Holländer)
UniBasel Contributors:Holländer, Georg
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1521-4141 (Electronic) 0014-2980 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:31 May 2020 17:47
Deposited On:31 May 2020 17:47

Repository Staff Only: item control page