Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population

Hasse, B. and Tarr, P. E. and Marques-Vidal, P. and Waeber, G. and Preisig, M. and Mooser, V. and Valeri, F. and Djalali, S. and Andri, R. and Bernasconi, E. and Calmy, A. and Cavassini, M. and Vernazza, P. and Battegay, M. and Weber, R. and Senn, O. and Vollenweider, P. and Ledergerber, B. and CoLaus Cohort, Fire and the Swiss, H. I. V. Cohort Study and Aubert, V. and Barth, J. and Battegay, M. and Bernasconi, E. and Boni, J. and Bucher, H. C. and Burton-Jeangros, C. and Calmy, A. and Cavassini, M. and Egger, M. and Elzi, L. and Fehr, J. and Fellay, J. and Furrer, H. and Fux, C. A. and Gorgievski, M. and Gunthard, H. and Haerry, D. and Hasse, B. and Hirsch, H. H. and Hosli, I. and Kahlert, C. and Kaiser, L. and Keiser, O. and Klimkait, T. and Kouyos, R. and Kovari, H. and Ledergerber, B. and Martinetti, G. and Martinez de Tejada, B. and Metzner, K. and Muller, N. and Nadal, D. and Pantaleo, G. and Rauch, A. and Regenass, S. and Rickenbach, M. and Rudin, C. and Schoni-Affolter, F. and Schmid, P. and Schultze, D. and Schupbach, J. and Speck, R. and Staehelin, C. and Tarr, P. and Telenti, A. and Trkola, A. and Vernazza, P. and Weber, R. and Yerly, S. and Jean-Michel, A. and Murielle, B. and Jean Michel, G. and Christoph, H. and Thomas, L. and Pedro, M. V. and Vincent, M. and Fred, P. and Martin, P. and Peter, V. and Roland, V. K. and Aidacic, V. and Gerard, W. and Jurg, B. and Markus, B. and Heinz, B. and Martin, B. and Hans-Ulrich, B. and Ivo, B. and Reto, C. and Isabelle, C. and Corinne, C. and Sima, D. and Peter, D. and Simone, E. and Andrea, F. and Markus, F. and Claudius, F. and Jakob, F. and Ali, G. M. and Matthias, G. and Denis, H. and Marcel, H. and Walter, H. and Simon, H. and Felix, H. and Paul, H. and Eva, K. and Vladimir, K. and Daniel, K. and Stephan, K. and Beat, K. and Benedict, K. and Heidi, K. and Vesna, L. and Giovanni, L. and Werner, L. H. and Phillippe, L. and Severin, L. and Christoph, M. and Jurgen, M. and Damian, M. and Werner, M. and Titus, M. and Valentina, N. and Jakob, R. and Thomas, R. and Hana, S. and Frank, S. and Georg, S. and Oliver, S. and Pietro, S. and Jacques, S. and Alfred, S. and Alois, S. and Claudia, S. and Othmar, S. and Phuoc, T. T. and Marco, V. and Alessandro, V. and Rene, V. A. and Hans, W. and Fritz, W. and Johanna, W. S. and Joseph, W. and Marco, Z.. (2015) Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population. Open Forum Infectious Diseases, 2 (3). ofv108.

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Official URL: https://edoc.unibas.ch/61904/

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Background. Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods. We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records. The incidence of the respective endpoints were assessed among SHCS and CoLaus participants. Poisson regression models were adjusted for age, sex, body mass index, and smoking. Results. Overall, 74 291 participants contributed data to prevalence analyses (3230 HIV-infected; 71 061 controls). In CoLaus, FIRE, and SHCS, multimorbidity was present among 26%, 13%, and 27% of participants. Compared with nonsmoking individuals from CoLaus, the incidence of cardiovascular disease was elevated among smoking individuals but independent of HIV status (HIV-negative smoking: incidence rate ratio [IRR] = 1.7, 95% confidence interval [CI] = 1.2-2.5; HIV-positive smoking: IRR = 1.7, 95% CI = 1.1-2.6; HIV-positive nonsmoking: IRR = 0.79, 95% CI = 0.44-1.4). Compared with nonsmoking HIV-negative persons, multivariable Poisson regression identified associations of HIV infection with hypertension (nonsmoking: IRR = 1.9, 95% CI = 1.5-2.4; smoking: IRR = 2.0, 95% CI = 1.6-2.4), kidney (nonsmoking: IRR = 2.7, 95% CI = 1.9-3.8; smoking: IRR = 2.6, 95% CI = 1.9-3.6), and liver disease (nonsmoking: IRR = 1.8, 95% CI = 1.4-2.4; smoking: IRR = 1.7, 95% CI = 1.4-2.2). No evidence was found for an association of HIV-infection or smoking with diabetes mellitus. Conclusions. Multimorbidity is more prevalent and incident in HIV-positive compared with HIV-negative individuals. Smoking, but not HIV status, has a strong impact on cardiovascular risk and multimorbidity.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:Hirsch, Hans H. and Klimkait, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Nov 2018 19:12
Deposited On:13 Nov 2018 19:12

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