A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker

Heinzelmann-Schwarz, Viola A. and Nixdorf, Sheri and Valadan, Mehrnaz and Diczbalis, Monica and Olivier, Jake and Otton, Geoff and Fedier, André and Hacker, Neville F. and Scurry, James P.. (2014) A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker. International journal of molecular medicine, 33 (4). pp. 784-794.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61863/

Downloads: Statistics Overview


Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate predictor of prognosis. We thus performed a clinicopathological and literature review to identify suitable predictors of prognosis and survival and investigated the expression of c-KIT (by immunohistochemistry) in patients with vulvar melanoma (n=33) from the Gynaecological Cancer Centres of the Royal Hospital for Women (Sydney, Australia) and John Hunter Hospital (Newcastle, Australia). Our series of 33 patients fitted the expected clinical profile of older women: delayed presentation, high stage, limited response to treatment and poor prognosis. We identified 3 patients (9.1%) with lichen sclerosus associated with melanoma in situ, although no lichen sclerosus was found in the areas of invasive melanoma. No patient had vulvar nevi. We identified a) Breslow's depth, b) an absence of any of the pathological risk factors, such as satellitosis, in-transit metastasis, lymphovascular space invasion (LVSI) and dermal mitosis, c) removal of inguino-femoral lymph nodes, d) lateral margin of <1 cm, and e) c-KIT expression as valuable prognostic predictors for disease-free survival. We conclude that c-KIT expression is, apart from Breslow's depth, another valuable predictor of prognosis and survival. Lichen sclerosus may be associated with vulvar melanoma.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Gynecological Research (Heinzelmann)
UniBasel Contributors:Heinzelmann, Viola
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:D.A. Spandidos
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:23 Jul 2020 16:08
Deposited On:23 Jul 2020 16:08

Repository Staff Only: item control page