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Analysis of the functional role of nucleoporin Nup214 in nuclear transport and other cellular processes

Paulillo, Sara Maria. Analysis of the functional role of nucleoporin Nup214 in nuclear transport and other cellular processes. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_7931

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Abstract

Nuclear pore complexes (NPCs) provide the sole gateway between the cytoplasm
and nucleus of eukaryotic cells and they act as mediator of all macromolecular exchange
between these distinct subcellular compartments. Whereas the structure of the plant NPC
has been studied already decades ago by distinct electron microscopy approaches, the
characterization of its molecular components, the nucleoporins, has still remained largely
elusive. In this review, we will focus on recent progress that has been made regarding the
molecular composition of the plant NPC as well as on its role in nucleocytoplasmic transport
and other processes, such as host-pathogen signaling in plants. In addition, we will discuss
recent fi ndings on the vertebrate nucleoporins that appear to be absent in the plant NPC and
their implications in cell organization related processes and diseases.
Advisors:Aebi, Ueli
Committee Members:Fahrenkrog, Birthe and Mayans, Olga
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Aebi)
UniBasel Contributors:Aebi, Ueli and Fahrenkrog, Birthe and Mayans, Olga
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:7931
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:192
Language:English
Identification Number:
Last Modified:22 Jan 2018 15:50
Deposited On:13 Feb 2009 16:06

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