Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF

Giaglis, Stavros and Stoikou, Maria and Sur Chowdhury, Chanchal and Schaefer, Guenther and Grimolizzi, Franco and Rossi, Simona W. and Hoesli, Irene Mathilde and Lapaire, Olav and Hasler, Paul and Hahn, Sinuhe. (2016) Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF. Frontiers in Immunology, 7. p. 565.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61778/

Downloads: Statistics Overview


Human pregnancy is associated with a mild pro-inflammatory state, characterized by circulatory neutrophil activation. In order to explore the mechanism underlying this alteration, we examined NETosis during normal gestation. Our data indicate that neutrophils exhibit a pro-NETotic state, modulated in a multimodal manner during pregnancy. In general, circulatory granulocyte colony-stimulating factor, the levels of which increase during gestation, promotes neutrophil extracellular trap (NET) formation. Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen. A complex interaction between estrogen and progesterone arises, wherein progesterone restrains the NETotic process. In this state, extensive histone citrullination is evident, yet full NETosis is inhibited. This coincides with the inability of neutrophil elastase to translocate from the cytoplasm to the nucleus and is regulated by progesterone. Our findings provide new insight concerning gestational and hormone-driven pathologies, since neutrophil recruitment, activation, and NET release could be associated with excessive endothelial and placental injury.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Prenatal Medicine (Hahn)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Immunoregulation (Rossi)
UniBasel Contributors:Rossi Girard, Simona and Hahn, Sinuhe
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Aug 2020 11:43
Deposited On:03 Aug 2020 11:43

Repository Staff Only: item control page