B Cells and Autoantibodies in Multiple Sclerosis

Probstel, A. K. and Sanderson, N. S. and Derfuss, T.. (2015) B Cells and Autoantibodies in Multiple Sclerosis. International Journal of Molecular Sciences , 16 (7). pp. 16576-16592.

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Official URL: https://edoc.unibas.ch/61678/

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While over the past decades T cells have been considered key players in the pathogenesis of multiple sclerosis (MS), it has only recently become evident that B cells have a major contributing role. Our understanding of the role of B cells has evolved substantially following the clinical success of B cell-targeting therapies and increasing experimental evidence for significant B cell involvement. Rather than mere antibody-producing cells, it is becoming clear that they are team players with the capacity to prime and regulate T cells, and function both as pro- and anti-inflammatory mediators. However, despite tremendous efforts, the target antigen(s) of B cells in MS have yet to be identified. The first part of this review summarizes the clinical evidence and results from animal studies pointing to the relevance of B cells in the pathogenesis of MS. The second part gives an overview of the currently known potential autoantigen targets. The third part recapitulates and critically appraises the currently available B cell-directed therapies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
UniBasel Contributors:Derfuss, Tobias Johannes
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Molecular Diversity Preservation International (MDPI)
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 Oct 2018 17:02
Deposited On:23 Oct 2018 17:02

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