Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder

Witt, Stephanie H. and Kleindienst, Nikolaus and Frank, Josef and Treutlein, Jens and Muhleisen, Thomas W. and Degenhardt, Franziska and Jungkunz, Martin and Krumm, Bertram and Cichon, Sven and Tadic, André and Dahmen, Norbert and Schwarze, Cornelia E. and Schott, Björn H. and Dietl, Lydia and Nöthen, Markus M. and Mobascher, Arian and Lieb, Klaus and Roepke, Stefan and Rujescu, Dan and Rietschel, Marcella and Schmahl, Christian and Bohus, Martin. (2014) Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder. Psychiatric Genetics, 24 (6). pp. 262-265.

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Official URL: https://edoc.unibas.ch/61592/

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The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case-control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Sex-specific analysis showed that this signal was present only in women. This is the first report of an association between a BD risk gene and BPD where selection was not based on a priori hypotheses about its function, but on an unbiased hypothesis-free screening of the genome. Genome-wide association data of large samples of BPD are warranted and will eventually identify new risk genes and the overlap between BPD and BD if it exists.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Human Genetics (Cichon)
UniBasel Contributors:Cichon, Sven
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Jul 2020 14:30
Deposited On:20 Jul 2020 14:30

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