Diepenbruck, M. and Christofori, G.. (2016) Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe? Current Opinion in Cell Biolog, 43. pp. 7-13.
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Official URL: https://edoc.unibas.ch/61498/
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Abstract
An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during embryonic development and organogenesis. During an EMT, epithelial cells lose their polarized organization and acquire migratory and invasive capabilities. While a plethora of experimental results have indicated that manipulating an EMT also affects cancer metastasis, its reverse process, a mesenchymal to epithelial transition (MET), seems to support metastatic outgrowth in distant organs. Moreover, recent reports investigating cancer cells circulating in the blood stream or employing genetic lineage-tracing have questioned a critical role of an EMT in metastasis formation. Hence, we need to better understand the molecular networks underlying the cell plasticity conferred by an EMT or a MET and its functional contribution to malignant tumor progression.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Tumor Biology (Christofori) |
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UniBasel Contributors: | Christofori, Gerhard M. |
Item Type: | Article, refereed |
Article Subtype: | Further Journal Contribution |
e-ISSN: | 1879-0410 |
Note: | Publication type according to Uni Basel Research Database: Journal item |
Related URLs: | |
Identification Number: |
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Last Modified: | 05 Mar 2019 18:54 |
Deposited On: | 05 Mar 2019 18:54 |
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