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Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Andersen, Zorana J. and Pedersen, Marie and Weinmayr, Gudrun and Stafoggia, Massimo and Galassi, Claudia and Jørgensen, Jeanette T. and Sommar, Johan N. and Forsberg, Bertil and Olsson, David and Oftedal, Bente and Aasvang, Gunn Marit and Schwarze, Per and Pyko, Andrei and Pershagen, Göran and Korek, Michal and Faire, Ulf De and Östenson, Claes-Göran and Fratiglioni, Laura and Eriksen, Kirsten T. and Poulsen, Aslak H. and Tjønneland, Anne and Bräuner, Elvira Vaclavik and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Jaensch, Andrea and Nagel, Gabriele and Lang, Alois and Wang, Meng and Tsai, Ming-Yi and Grioni, Sara and Marcon, Alessandro and Krogh, Vittorio and Ricceri, Fulvio and Sacerdote, Carlotta and Migliore, Enrica and Vermeulen, Roel and Sokhi, Ranjeet and Keuken, Menno and de Hoogh, Kees and Beelen, Rob and Vineis, Paolo and Cesaroni, Giulia and Brunekreef, Bert and Hoek, Gerard and Raaschou-Nielsen, Ole. (2018) Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE). Neuro-oncology, 20 (3). pp. 420-432.

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Abstract

Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.; In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.; Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95% CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.; We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Tsai, Ming-Yi and de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1522-8517
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:08 Jun 2018 14:51
Deposited On:08 Jun 2018 14:51

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