Organization and functions of mGlu and GABAB receptor complexes

Pin, Jean-Philippe and Bettler, Bernhard. (2016) Organization and functions of mGlu and GABAB receptor complexes. Nature, 540 (7631). pp. 60-68.

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The neurotransmitters glutamate and gamma-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a large extracellular domain and a mandatory dimeric structure. Recent studies have revealed how these receptors are activated through multiple allosteric interactions between subunit domains. It emerges that the molecular complexity of these receptors is further increased through association with trafficking, effector and regulatory proteins. The structure and composition of these receptors present opportunities for therapeutic intervention in mental health and neurological disorders.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
ISSN:1476-4687 (Electronic) 0028-0836 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:19 Jan 2019 18:34
Deposited On:19 Jan 2019 18:34

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