Memo is a copper-dependent redox protein with an essential role in migration and metastasis

MacDonald, Gwen and Nalvarte, Ivan and Smirnova, Tatiana and Vecchi, Manuela and Aceto, Nicola and Dolemeyer, Arno and Frei, Anna and Lienhard, Susanne and Wyckoff, Jeffrey and Hess, Daniel and Seebacher, Jan and Keusch, Jeremy J. and Gut, Heinz and Salaun, Daniele and Mazzarol, Giovanni and Disalvatore, Davide and Bentires-Alj, Mohamed and Di Fiore, Pier Paolo and Badache, Ali and Hynes, Nancy E.. (2014) Memo is a copper-dependent redox protein with an essential role in migration and metastasis. Science Signaling, 7 (329). ra56.

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Memo is an evolutionarily conserved protein with a critical role in cell motility. We found that Memo was required for migration and invasion of breast cancer cells in vitro and spontaneous lung metastasis from breast cancer cell xenografts in vivo. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. Memo was also required for the sustained production of the ROS O2- by NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 1 (NOX1) in breast cancer cells. Memo abundance was increased in <40% of the primary breast tumors tested, was correlated with clinical parameters of aggressive disease, and was an independent prognostic factor of early distant metastasis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tumor Heterogeneity Metastasis and Resistance (Bentires-Alj)
UniBasel Contributors:Bentires-Alj, Mohamed
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Dec 2020 16:56
Deposited On:09 Dec 2020 16:56

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