edoc

Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy

Stolz, Martin and Gottardi, Riccardo and Raiteri, Roberto and Miot, Sylvie and Martin, Ivan and Imer, Raphael and Staufer, Urs and Raducanu, Aurelia and Dueggelin, Marcel and Baschong, Werner and Daniels, A. U. and Friederich, Niklaus F. and Aszodi, Attila and Aebi, Ueli. (2009) Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy. Nature nanotechnology, Vol. 4. pp. 186-192.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5259458

Downloads: Statistics Overview

Abstract

The pathological changes in osteoarthritis-a degenerative joint disease prevalent among older people-start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation of cartilage. Early detection and the ability to monitor the progression of osteoarthritis are therefore important for developing effective therapies. Here, we show that indentation-type atomic force microscopy can monitor age-related morphological and biomechanical changes In the hips of normal and osteoarthritic mice. Early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements could similarly be detected using this method. Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis In situ.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tissue Engineering (Martin)
03 Faculty of Medicine > Departement Zahnmedizin > Klinik Zahnärztliche Chirurgie > Kieferchirurgie (Lambrecht)
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Rheumatologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Rheumatologie
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Aebi)
UniBasel Contributors:Baschong, Werner and Friederich, Niklaus F. and Daniels, A.U. Dan and Martin, Ivan and Aebi, Ueli
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1748-3395
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:07 Jun 2018 14:07
Deposited On:22 Mar 2012 13:32

Repository Staff Only: item control page