Protein binders and their applications in developmental biology

Harmansa, Stefan and Affolter, Markus. (2018) Protein binders and their applications in developmental biology. Development, 145 (2). pp. 1-13.

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Official URL: https://edoc.unibas.ch/59546/

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Developmental biology research would benefit greatly from tools that enable protein function to be regulated, both systematically and in a precise spatial and temporal manner, in vivo In recent years, functionalized protein binders have emerged as versatile tools that can be used to target and manipulate proteins. Such protein binders can be based on various scaffolds, such as nanobodies, designed ankyrin repeat proteins (DARPins) and monobodies, and can be used to block or perturb protein function in living cells. In this Primer, we provide an overview of the protein binders that are currently available and highlight recent progress made in applying protein binder-based tools in developmental and synthetic biology.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:The Company of Biologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Oct 2018 18:19
Deposited On:15 Oct 2018 18:24

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