Hajishengallis, George and Reis, Edimara S. and Mastellos, Dimitrios C. and Ricklin, Daniel and Lambris, John D.. (2017) Novel mechanisms and functions of complement. Nature Immunology, 18 (12). pp. 1288-1298.
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Official URL: http://edoc.unibas.ch/58346/
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Abstract
Progress at the beginning of the 21st century transformed the perception of complement from that of a blood-based antimicrobial system to that of a global regulator of immunity and tissue homeostasis. More recent years have witnessed remarkable advances in structure-function insights and understanding of the mechanisms and locations of complement activation, which have added new layers of complexity to the biology of complement. This complexity is readily reflected by the multifaceted and contextual involvement of complement-driven networks in a wide range of inflammatory and neurodegenerative disorders and cancer. This Review provides an updated view of new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular Pharmacy (Ricklin) |
|---|---|
| UniBasel Contributors: | Ricklin, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 1529-2916 |
| e-ISSN: | 1529-2916 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 30 May 2018 08:51 |
| Deposited On: | 30 May 2018 08:51 |
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