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Copper is a Cofactor of the Formylglycine-Generating Enzyme

Knop, Matthias and Dang, Thanh Quy and Jeschke, Gunnar and Seebeck, Florian P.. (2017) Copper is a Cofactor of the Formylglycine-Generating Enzyme. ChemBioChem, 18 (2). pp. 161-165.

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Official URL: http://edoc.unibas.ch/58311/

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Abstract

Formylglycine-generating enzyme (FGE) is an O2 -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that CuI is an integral cofactor of this enzyme and binds with high affinity (KD =of 10-17 m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
UniBasel Contributors:Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1439-4227
e-ISSN:1439-7633
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Jan 2018 13:49
Deposited On:05 Jan 2018 13:49

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