Knop, Matthias and Dang, Thanh Quy and Jeschke, Gunnar and Seebeck, Florian P.. (2017) Copper is a Cofactor of the Formylglycine-Generating Enzyme. ChemBioChem, 18 (2). pp. 161-165.
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Abstract
Formylglycine-generating enzyme (FGE) is an O2 -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that CuI is an integral cofactor of this enzyme and binds with high affinity (KD =of 10-17 m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck) |
|---|---|
| UniBasel Contributors: | Seebeck, Florian Peter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1439-4227 |
| e-ISSN: | 1439-7633 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 25 Feb 2020 08:45 |
| Deposited On: | 05 Jan 2018 13:49 |
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