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On the Formation of Digits and Joints during Limb Development

Hiscock, Tom W. and Tschopp, Patrick and Tabin, Clifford J.. (2017) On the Formation of Digits and Joints during Limb Development. Developmental Cell, 41 (5). pp. 459-465.

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Official URL: http://edoc.unibas.ch/57265/

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Abstract

Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Zoologie > Regulatory Evolution (Tschopp)
UniBasel Contributors:Tschopp, Patrick
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1534-5807
e-ISSN:1878-1551
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 May 2018 08:12
Deposited On:16 May 2018 08:12

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