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Protection of host cells by complement regulators

Schmidt, Christoph Q. and Lambris, John D. and Ricklin, Daniel. (2016) Protection of host cells by complement regulators. Immunological Reviews, 274 (1). pp. 152-171.

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Official URL: http://edoc.unibas.ch/52826/

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Abstract

The complement cascade is an ancient immune-surveillance system that not only provides protection from pathogen invasion but has also evolved to participate in physiological processes to maintain tissue homeostasis. The alternative pathway (AP) of complement activation is the evolutionarily oldest part of this innate immune cascade. It is unique in that it is continuously activated at a low level and arbitrarily probes foreign, modified-self, and also unaltered self-structures. This indiscriminate activation necessitates the presence of preformed regulators on autologous surfaces to spare self-cells from the undirected nature of AP activation. Although the other two canonical complement activation routes, the classical and lectin pathways, initiate the cascade more specifically through pattern recognition, their activity still needs to be tightly controlled to avoid excessive reactivity. It is the perpetual duty of complement regulators to protect the self from damage inflicted by inadequate complement activation. Here, we review the role of complement regulators as preformed mediators of defense, explain their common and specialized functions, and discuss selected cases in which alterations in complement regulators lead to disease. Finally, rational engineering approaches using natural complement inhibitors as potential therapeutics are highlighted.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Ricklin, Daniel
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Wiley-Blackwell Publishing
ISSN:0105-2896
e-ISSN:1600-065X
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:25 Oct 2017 13:39
Deposited On:25 Oct 2017 13:39

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