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Contributions of low molecule number and chromosomal positioning to stochastic gene expression

Becskei, Attila and Kaufmann, Benjamin B. and van Oudenaarden, Alexander. (2005) Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nature Genetics, 37 (9). pp. 937-944.

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Official URL: http://edoc.unibas.ch/46412/

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Abstract

The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes.
Faculties and Departments:05 Faculty of Science
05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Synthetic Microbiology (Becskei)
UniBasel Contributors:Becskei, Attila
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1061-4036
e-ISSN:1546-1718
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Nov 2017 08:18
Deposited On:23 Nov 2017 08:18

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