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Multitarget network strategies to influence memory and forgetting: the Ras/MAPK pathway as a novel option

Gyurkó, Márton Dávid and Steták, Attila and Sőti, Csaba and Csermely, Péter. (2015) Multitarget network strategies to influence memory and forgetting: the Ras/MAPK pathway as a novel option. Mini Reviews in Medicinal Chemistry, 15 (8). pp. 696-704.

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Official URL: http://edoc.unibas.ch/40788/

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Abstract

The Ras/mitogen activated protein kinase (MAPK) pathway has key importance in development, cell differentiation and senescence, tumorigenesis, learning and memory. The clinical manifestations associated with this highly conserved pathway are called RASopathies. Phenotypic features are diverse and overlapping, but cognitive impairment is a common symptom. Here, we propose an approach based on molecular networks that link learning, memory and forgetting to the RASopathies and various neurodegenerative and neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease and autism spectrum disorders. We demonstrate the cross-talks of the molecular pathways in RASopathies and memory and the role of compartmentalization in these processes. The approved drugs are also overviewed, and C. elegans is proposed as a viable model system for experimental exploration and compound target prediction.n.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Stetak, Attila
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Publ.
ISSN:1389-5575
e-ISSN:1875-5607
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Nov 2017 10:15
Deposited On:02 Nov 2017 10:15

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