Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS ONE, Vol. 10, H. 8 , e0135556.
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Official URL: http://edoc.unibas.ch/dok/A6420002
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Abstract
Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria. Since drug development is lengthy and expensive, a drug repurposing strategy offers an attractive fast-track approach to speed up the process. A set of 100 registered drugs with drug repositioning potential for neglected diseases was assembled and tested in vitro against four protozoan parasites associated with the aforementioned diseases. Several drugs and drug classes showed in vitro activity in those screening assays. The results are critically reviewed and discussed in the perspective of a follow-up drug repositioning strategy where R&D has to be addressed with limited resources.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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UniBasel Contributors: | Kaiser, Marcel and Mäser, Pascal and Brun, Reto |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Public Library of Science |
e-ISSN: | 1932-6203 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Related URLs: | |
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edoc DOI: | |
Last Modified: | 31 Aug 2018 06:38 |
Deposited On: | 04 Sep 2015 14:31 |
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