System-level analysis of Salmonella metabolism during infection

Bumann, Dirk. (2009) System-level analysis of Salmonella metabolism during infection. Current Opinion in Microbiology, 12 (5). pp. 559-567.

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Official URL: http://edoc.unibas.ch/dok/A5259796

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Infectious diseases represent a major threat to human health. To develop urgently needed new control strategies, a transition from research focusing on individual factors to a more integrated system-level analysis might be needed. Such an approach faces great challenges and might require development of new concepts in large-scale data analysis. Here, I discuss for the well-characterized model pathogen Salmonella, how extensively studied metabolism can be used as a training field for infection biology at the systems level. Extensive experimental data can be analyzed in context using metabolic network visualization tools and in silico modeling based on genome-scale metabolic reconstructions. Suitable approaches to obtain still missing comprehensive quantitative data on Salmonella nutrition in infected host tissues are described. Such an integrated investigation of Salmonella metabolism during infection will enable an unprecedented large-scale understanding of pathogen in vivo activities, help to evaluate concepts and strategies for system-level analysis of host/pathogen interactions in general, and provide a basis for rational development of novel antimicrobials and efficacious live vaccines.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Nov 2017 11:17
Deposited On:22 Mar 2012 13:23

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