Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity

Donath, M. Y. and Dalmas, E. and Sauter, N. S. and Boni-Schnetzler, M.. (2013) Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. Cell metabolism, Vol. 17, H. 6. pp. 860-872.

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Official URL: http://edoc.unibas.ch/dok/A6338615

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The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by infection or injury and plays a role in response to overnutrition. Initially, this metabolic activation of the immune system is a physiological response, but it may become deleterious with time. Therefore, therapeutic interventions should aim at modulating the immune system rather than simply damping it. In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1beta pathway, and clinical translation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Diabetes Research (Donath)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:10 Apr 2015 09:13

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