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Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

Hirt, Christian and Eppenberger-Castori, Serenella and Sconocchia, Giuseppe and Iezzi, Giandomenica and Tornillo, Luigi and Terracciano, Luigi and Spagnoli, Giulio C. and Droeser, Raoul A.. (2013) Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis. OncoImmunology, Vol. 2, H. 10 , e25990.

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Official URL: http://edoc.unibas.ch/dok/A6338102

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Abstract

The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+ cells correlates with improved patient survival independently of other histopathological parameters, including disease stage.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Oncology Surgery (Spagnoli)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunotherapy (Iezzi)
UniBasel Contributors:Spagnoli, Giulio C. and Iezzi, Giandomenica
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Landes Bioscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:32
Deposited On:06 Mar 2015 07:44

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