Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798.
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Official URL: http://edoc.unibas.ch/dok/A6233661
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Abstract
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo inhibitor of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT; sleeping sickness). In this Letter, chemical derivatization of cynaropicrin and the structure-activity-relationship (SAR) study against T. brucei is described.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel and Brun, Reto |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 18 Jul 2014 09:10 |
| Deposited On: | 18 Jul 2014 09:10 |
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