Monnard, Fabien W. and Nogueira, Elisa S. and Heinisch, Tillmann and Schirmer, Tilman and Ward, Thomas R.. (2013) Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes : the Asymmetric Transfer Hydrogenation of Imines. Chemical Science, 4 (6). p. 3269.
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Abstract
In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asymmetric transfer hydrogenation of imines. Critical cofactor–protein interactions revealed by the X-ray structure of [(η5-Cp*)Ir(pico 4)Cl] 9 ⊂ WT hCA II were genetically optimized to improve the catalytic performance of the artificial metalloenzyme (68% ee, kcat/KM 6.11 × 10−3 min−1 mM−1).
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
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| UniBasel Contributors: | Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R. R. and Monnard, Fabien |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2041-6520 |
| e-ISSN: | 2041-6539 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 10 Apr 2017 13:45 |
| Deposited On: | 31 Jan 2014 09:50 |
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