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PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors

de Quervain, Dominique J.-F. and Kolassa, Iris-Tatjana and Ackermann, Sandra and Aerni, Amanda and Boesiger, Peter and Demougin, Philippe and Elbert, Thomas and Ertl, Verena and Gschwind, Leo and Hadziselimovic, Nils and Hanser, Edveena and Heck, Angela and Hieber, Petra and Huynh, Kim-Dung and Klarhöfer, Markus and Luechinger, Roger and Rasch, Björn and Scheffler, Klaus and Spalek, Klara and Stippich, Christoph and Vogler, Christian and Vukojevic, Vanja and Stetak, Attila and Papassotiropoulos, Andreas. (2012) PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors. Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, H. 22. pp. 8746-8751.

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Official URL: http://edoc.unibas.ch/dok/A6083590

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Abstract

Strong memory of a traumatic event is thought to contribute to the development and symptoms of posttraumatic stress disorder (PTSD). Therefore, a genetic predisposition to build strong memories could lead to increased risk for PTSD after a traumatic event. Here we show that genetic variability of the gene encoding PKCα (PRKCA) was associated with memory capacity--including aversive memory--in nontraumatized subjects of European descent. This finding was replicated in an independent sample of nontraumatized subjects, who additionally underwent functional magnetic resonance imaging (fMRI). fMRI analysis revealed PRKCA genotype-dependent brain activation differences during successful encoding of aversive information. Further, the identified genetic variant was also related to traumatic memory and to the risk for PTSD in heavily traumatized survivors of the Rwandan genocide. Our results indicate a role for PKCα in memory and suggest a genetic link between memory and the risk for PTSD.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
UniBasel Contributors:Heck, Angela and Hanser, Edveena and Hadziselimovic, Nils and Rasch, Björn and Vukojevic, Vanja and Demougin, Philippe and Scheffler, Klaus and Ackermann, Sandra and Gschwind, Leo and Papassotiropoulos, Andreas and Vogler, Christian and Sifalakis, Klara and Stetak, Attila and Stippich, Christoph and Aerni, Amanda and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:National Academy of Sciences
ISSN:0027-8424
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Mar 2014 13:13
Deposited On:26 Apr 2013 06:56

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