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Uses of mosquito-stage transmission-blocking vaccines against Plasmodium falciparum

Smith, T. A. and Chitnis, N. and Briët, O. J. and Tanner, M.. (2011) Uses of mosquito-stage transmission-blocking vaccines against Plasmodium falciparum. Trends in parasitology, 27 (5). pp. 190-196.

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Official URL: http://edoc.unibas.ch/dok/A6002387

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Abstract

A quantitative framework is used to explore the potential applications and probable effects of sexual stage or mosquito stage transmission blocking vaccines (TBVs) against malaria. The combination of TBVs with biocides or other malaria vaccines will increase chances of interrupting transmission, whereas the value of TBVs for morbidity control will be limited. Vaccine combination will also protect against selection of insensitive parasites. Simulations indicate that TBVs will reduce risks of reestablishment of transmission when vector control is withdrawn. Simple mathematical analysis shows that efficacy and coverage are equally important, implying that a vaccine that requires a small number of doses (ideally one) is preferable to one that is difficult to deliver, even if this entails accepting a lower efficacy
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Infectious Disease Modelling (Smith)
UniBasel Contributors:Smith, Thomas A. and Tanner, Marcel and Chitnis, Nakul and Briët, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Jul 2018 12:43
Deposited On:08 Nov 2012 16:19

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