Dürrenberger, Marc and Heinisch, Tillmann and Wilson, Yvonne and Rossel, Thibaud and Nogueira, Elisa and Knörr, Livia and Mutschler, Annette and Kersten, Karoline and Zimbron, Mallcom and Pierron, Julien and Schirmer, Tilman and Ward, Thomas R.. (2011) Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines. Angewandte Chemie International Edition, 50 (13). pp. 3026-3029.
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Official URL: http://edoc.unibas.ch/dok/A6002018
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Abstract
Man-made activity: Introduction of a biotinylated iridium piano stool complex within streptavidin affords an artificial imine reductase (see scheme). Saturation mutagenesis allowed optimization of the activity and the enantioselectivity of this metalloenzyme, and its X-ray structure suggests that a nearby lysine residue acts as a proton source during the transfer hydrogenation.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schirmer) |
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| UniBasel Contributors: | Ward, Thomas R. R. and Dürrenberger, Marc and Heinisch, Tillmann and Wilson, Yvonne Martha and Rossel, Thibaud and Nogueira, Elisa S. and Knörr, Livia and Schirmer, Tilman |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 21 Mar 2023 11:03 |
| Deposited On: | 08 Nov 2012 16:10 |
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