Structural analysis of the nuclear pore complex by integrated approaches

Elad, N. and Maimon, T. and Frenkiel-Krispin, D. and Lim, R. Y. H. and Medalia, O.. (2009) Structural analysis of the nuclear pore complex by integrated approaches. Current Opinion in Structural Biology, Vol. 19, H. 2. pp. 226-232.

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Official URL: http://edoc.unibas.ch/dok/A5259683

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In eukaryotic cells, the nucleus is surrounded by a double membrane system, the nuclear envelope (NE), in which the outer membrane is continuous with the endoplasmic reticulum (ER). Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules. Being the sole gateways for import and export to and from the nucleus, NPCs regulate the nucleocytoplasmic transport of macromolecules in a highly selective manner to maintain cellular functions. The large size and complexity of these multimolecular assemblies, which are composed of approximately 30 different proteins (termed nucleoporins), present a major challenge for structural biologists. Here, we discuss the latest structural findings related to the functional organization of the NPC.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim)
UniBasel Contributors:Lim, Roderick Y.H.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Current Biology
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:22
Deposited On:14 Sep 2012 07:15

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