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Influence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium

Crull, K. and Bumann, D. and Weiss, S.. (2011) Influence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium. FEMS Immunology and Medical Microbiology, 62 (1). pp. 75-83.

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Official URL: http://edoc.unibas.ch/dok/A5844168

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Abstract

Administration of facultative anaerobic bacteria like Salmonella enterica serovar Typhimurium (S. typhimurium) as anti-cancer treatment holds a great therapeutic potential. Here we tested different routes of application of S. typhimurium with regard to tumor colonization and therapeutic efficacy. No differences between iv and ip infection were observed, often leading to a complete tumor clearance. In contrast, after oral application tumor colonization was inefficient and delayed. No therapeutic effect was observed under such conditions. We also could show that tumor invasion and colonization was independent of functional SPI 1 and SPI 2. Furthermore, tumor invasion and colonization did not require bacterial motility nor chemotactic responsiveness. The distribution of the bacteria within the tumor was independent of such functions.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0928-8244
e-ISSN:1574-695X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:27 Nov 2017 08:06
Deposited On:14 Sep 2012 06:38

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