Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Merker, Matthias and Blin, Camille and Mona, Stefano and Duforet-Frebourg, Nicolas and Lecher, Sophie and Willery, Eve and Blum, Michael G. B. and Rüsch-Gerdes, Sabine and Mokrousov, Igor and Aleksic, Eman and Allix-Béguec, Caroline and Antierens, Annick and Augustynowicz-Kopeć, Ewa and Ballif, Marie and Barletta, Francesca and Beck, Hans Peter and Barry, Clifton E. and Bonnet, Maryline and Borroni, Emanuele and Campos-Herrero, Isolina and Cirillo, Daniela and Cox, Helen and Crowe, Suzanne and Crudu, Valeriu and Diel, Roland and Drobniewski, Francis and Fauville-Dufaux, Maryse and Gagneux, Sébastien and Ghebremichael, Solomon and Hanekom, Madeleine and Hoffner, Sven and Jiao, Wei-Wei and Kalon, Stobdan and Kohl, Thomas A. and Kontsevaya, Irina and Lillebæk, Troels and Maeda, Shinji and Nikolayevskyy, Vladyslav and Rasmussen, Michael and Rastogi, Nalin and Samper, Sofia and Sanchez-Padilla, Elisabeth and Savic, Branislava and Shamputa, Isdore Chola and Shen, Adong and Sng, Li-Hwei and Stakenas, Petras and Toit, Kadri and Varaine, Francis and Vukovic, Dragana and Wahl, Céline and Warren, Robin and Supply, Philip and Niemann, Stefan and Wirth, Thierry. (2015) Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Nature genetics, Vol. 47, H. 3. pp. 242-249.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6373523

Downloads: Statistics Overview

Abstract

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Molecular Parasitology and Epidemiology (Beck)
UniBasel Contributors:	Ballif, Marie and Beck, Hans-Peter and Gagneux, Sebastien
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Nature Publ
ISSN:	1061-4036
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Document Document
Identification Number:	pmid: 25599400 doi: 10.1038/ng.3195
Last Modified:	05 Jun 2015 08:52
Deposited On:	05 Jun 2015 08:52

Repository Staff Only: item control page