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Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides

Hao, Hong-Dong and Wittlin, Sergio and Wu, Yikang. (2013) Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides. Chemistry : a European journal, Vol. 19, H. 23. pp. 7605-7619.

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Official URL: http://edoc.unibas.ch/dok/A6164961

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Abstract

Perhydrolysis of a sterically congested multifunctional epoxide was achieved in ethereal H2O2 with the aid of a recently developed Mo catalyst. The resulting hydroperoxide cyclized to give a 1,2,4-trioxane, which could be readily elaborated into qinghaosu and a range of novel analogues. Some of the compounds with two such trioxane moieties showed in vitro antimalarial activity comparable to or even better than that of artesunate or chloroquine.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Wittlin, Sergio
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley-VCH Verlag
ISSN:0947-6539
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Oct 2013 08:32
Deposited On:25 Oct 2013 08:32

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