Li, Y. and Hao, H. D. and Wittlin, S. and Wu, Y.. (2012) Simple analogues of Qinghaosu (Artemisinin). Chemistry : an Asian journal / an ACES journal, Vol. 7, H. 8. pp. 1881-1886.
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Official URL: http://edoc.unibas.ch/dok/A6094368
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Abstract
A series of 1,2,4-trioxanes were synthesized in which the key peroxy bonds were installed through a molybdenum-catalyzed perhydrolysis of the epoxy rings. A core structure was identified that may serve as a promising lead structure for further investigations because of its high antimalarial activity (comparable to that of artesunate and chloroquine), apparent potential for scale-up and derivatization, and facile monitoring/tracing by using UV light
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Wittlin, Sergio |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley-VCH |
| ISSN: | 1861-4728 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 16 Aug 2013 07:34 |
| Deposited On: | 16 Aug 2013 07:29 |
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