van den Elskamp, I. J. and Boden, B. and Dattola, V. and Knol, D. L. and Filippi, M. and Kappos, L. and Fazekas, F. and Wagner, K. and Pohl, C. and Sandbrink, R. and Polman, C. H. and Uitdehaag, B. M. J. and Barkhof, F.. (2010) Cerebral atrophy as outcome measure in short-term phase 2 clinical trials in multiple sclerosis. Neuroradiology, Vol. 52, H. 10. pp. 875-881.
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Official URL: http://edoc.unibas.ch/dok/A6006321
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Abstract
Cerebral atrophy is a compound measure of the neurodegenerative component of multiple sclerosis (MS) and a conceivable outcome measure for clinical trials monitoring the effect of neuroprotective agents. In this study, we evaluate the rate of cerebral atrophy in a 6-month period, investigate the predictive and explanatory value of other magnetic resonance imaging (MRI) measures in relation to cerebral atrophy, and determine sample sizes for future short-term clinical trials using cerebral atrophy as primary outcome measure.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos) |
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| UniBasel Contributors: | Kappos, Ludwig |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Springer |
| ISSN: | 0028-3940 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 26 Apr 2013 07:02 |
| Deposited On: | 26 Apr 2013 06:54 |
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