Kim, Young-Ho and Pierscianek, Daniela and Mittelbronn, Michel and Vital, Anne and Mariani, Luigi and Hasselblatt, Martin and Ohgaki, Hiroko. (2011) TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations. Journal of clinical pathology, Vol. 64, no. 10. pp. 850-852.
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Official URL: http://edoc.unibas.ch/dok/A6005903
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Abstract
Miscoding mutations of the TET2 gene, which encodes the ?-ketoglutarate-dependent enzyme that catalyses the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, thus producing DNA demethylation, have been detected in 10-25% of acute myeloid leukaemias lacking IDH1/2 mutations. Most low-grade diffuse gliomas carry IDH1/2 mutations (<85%), but molecular mechanisms of pathogenesis in those lacking IDH1/2 mutations remain to be elucidated.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Brain Tumor Biology (Mariani) |
|---|---|
| UniBasel Contributors: | Mariani, Luigi |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | British Medical Association |
| ISSN: | 0021-9746 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 31 Jan 2014 09:49 |
| Deposited On: | 31 Jan 2014 09:49 |
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