Lebrecht, Dirk and Venhoff, Ana C. and Kirschner, Janbernd and Wiech, Thorsten and Venhoff, Nils and Walker, Ulrich A.. (2009) Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats. JAIDS : journal of acquired immune deficiency syndromes : official publication of the International Retrovirology Association, Vol. 51. pp. 258-263.
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Official URL: http://edoc.unibas.ch/dok/A6005850
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Abstract
Tenofovir disoproxil fumarate (tenofovir DF) use has been associated with renal dysfunction and Fanconi syndrome. Tenofovir is taken up into renal tubules by anion transporters where high intracellular drug concentration may induce a functionally relevant depletion of mitochondrial DNA (mtDNA). We investigated if tenofovir may induce renal mtDNA depletion and respiratory chain dysfunction.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Rheumatologie 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Rheumatologie |
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| UniBasel Contributors: | Walker, Ulrich A. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Lippincott Williams & Wilkins |
| ISSN: | 1525-4135 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 01 Mar 2013 11:14 |
| Deposited On: | 01 Mar 2013 11:13 |
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