Seidel, Petra and Merfort, Irmgard and Tamm, Michael and Roth, Michael. (2010) Inhibition of NF- B and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts. Swiss medical weekly, Vol. 140 , w13132.
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Official URL: http://edoc.unibas.ch/dok/A6005588
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Abstract
QUESTION UNDER STUDY/PRINCIPLES: Dimethylfumarate (DMF) had been reported to reduce asthma symptoms and to improve the quality of life of asthma patients. Therefore, we assessed the anti-inflammatory and anti-remodeling effect of DMF on isolated lung fibroblasts, which are relevant to inflammatory lung diseases. We determined the effect of DMF on platelet derived growth factor (PDGF)-BB induced proliferation, as well as on PDGF-BB and tumor necrosis factor (TNF)- induced interleukin (IL)-6 secretion and on activation of activated protein (AP)-1 and nuclear factor kappaB (NF- B).
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Pulmonary Cell Research (Roth/Tamm) |
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| UniBasel Contributors: | Tamm, Michael and Roth-Chiarello, Michael |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | EMH |
| ISSN: | 1424-7860 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 24 May 2013 09:23 |
| Deposited On: | 24 May 2013 09:13 |
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