Wild, Damian and Wicki, Andreas and Mansi, Rosalba and Béhé, Martin and Keil, Boris and Bernhardt, Peter and Christofori, Gerhard and Ell, Peter J. and Mäcke, Helmut R.. (2010) Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT. Journal of nuclear medicine, Vol. 51, H. 7. pp. 1059-1067.
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Official URL: http://edoc.unibas.ch/dok/A6003740
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Abstract
Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma provides an attractive target for imaging. The first clinical trials demonstrated that GLP-1 receptor SPECT/CT using [Lys(40)(Ahx [6-aminohexanoic acid]-DOTA-(111)In)NH(2)]-exendin-4 can localize hardly detectable insulinomas. However, [Lys(40)(Ahx-DOTA-(111)In)NH(2)]-exendin-4 imaging has drawbacks related to the use of (111)In in that it is costly and carries a relatively high radiation burden for the patient. The aim of this study was the preclinical evaluation of [Lys(40)(Ahx-DOTA-(68)Ga)NH(2)]-exendin-4 for PET/CT and [Lys(40)(Ahx-hydrazinonicotinamide [HYNIC]-(99m)Tc)NH(2)]-exendin-4 for SPECT/CT.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Tumor Biology (Christofori) |
|---|---|
| UniBasel Contributors: | Christofori, Gerhard M. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Society of nuclear medicine |
| ISSN: | 0022-3123 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 07 Dec 2012 13:03 |
| Deposited On: | 07 Dec 2012 13:01 |
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