Barnadas, Celine and Koepfli, Cristian and Karunajeewa, Harin A. and Siba, Peter M. and Davis, Timothy M. E. and Mueller, Ivo. (2011) Characterization of treatment failure in efficacy trials of drugs against Plasmodium vivax by genotyping neutral and drug resistance-associated markers. Antimicrobial Agents and Chemotherapy, 55 (9). pp. 4479-4481.
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Official URL: http://edoc.unibas.ch/dok/A6002135
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Abstract
Plasmodium vivax intervention trials customarily report uncorrected treatment failure rates. Application of recrudescence-reinfection genotyping and drug resistance single-nucleotide polymorphism typing to a 4-arm comparative efficacy trial illustrated that molecular approaches can assist in understanding the relative contributions of true drug resistance (recurrent with same genotype) and new infections to treatment failure. The PCR-corrected adequate clinical and parasitologic response may constitute an informative secondary endpoint in future P. vivax drug trials
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Molecular Diagnostics (Felger) |
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| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| e-ISSN: | 1098-6596 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 11 Feb 2019 14:43 |
| Deposited On: | 08 Nov 2012 16:12 |
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