Farimani, M. M. and Taheri, S. and Ebrahimi, S. N. and Bahadori, M. B. and Khavasi, H. R. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2012) Hydrangenone, a new Isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters, 14 (1). pp. 166-169.
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Official URL: http://edoc.unibas.ch/dok/A6001710
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Abstract
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC(50) value of 1.4 muM against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Hamburger, Matthias and Zimmermann, Stefanie and Brun, Reto and Ebrahimi, Samad Nejad |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| e-ISSN: | 1523-7052 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 28 Nov 2017 10:47 |
| Deposited On: | 11 Oct 2012 15:19 |
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