edoc

The hypothalamic neuropeptide oxytocin is required for formation of the neurovascular interface of the pituitary

Gutnick, Amos and Blechman, Janna and Kaslin, Jan and Herwig, Lukas and Belting, Heinz-Georg and Affolter, Markus and Bonkowsky, Joshua L. and Levkowitz, Gil. (2011) The hypothalamic neuropeptide oxytocin is required for formation of the neurovascular interface of the pituitary. Developmental cell, Vol. 21, H. 4. pp. 642-654.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5848270

Downloads: Statistics Overview

Abstract

The hypothalamo-neurohypophyseal system (HNS) is the neurovascular structure through which the hypothalamic neuropeptides oxytocin and arginine-vasopressin exit the brain into the bloodstream, where they go on to affect peripheral physiology. Here, we investigate the molecular cues that regulate the neurovascular contact between hypothalamic axons and neurohypophyseal capillaries of the zebrafish. We developed a transgenic system in which both hypothalamic axons and neurohypophyseal vasculature can be analyzed in vivo. We identified the cellular organization of the zebrafish HNS as well as the dynamic processes that contribute to formation of the HNS neurovascular interface. We show that formation of this interface is regulated during development by local release of oxytocin, which affects endothelial morphogenesis. This cell communication process is essential for the establishment of a tight axovasal interface between the neurons and blood vessels of the HNS. We present a unique example of axons affecting endothelial morphogenesis through secretion of a neuropeptide.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:1534-5807
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:38

Repository Staff Only: item control page