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Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets

Jeon, Imjak and Gilli, Tiziana and Betz, Gabriele. (2011) Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets. Journal of pharmacy and bioallied sciences, Vol. 3, H. 2. pp. 213-220.

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Official URL: http://edoc.unibas.ch/dok/A5844683

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Abstract

Roll compaction was applied for the preparation of hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets. Matrix tablets made via roll compaction exhibited higher dosage uniformity and faster drug release than direct-compacted tablets. HPC viscosity grade, roll pressure, and milling speed affected tablet properties significantly. Roll compaction seems to be an adequate granulation method for the preparation of HPC-based matrix tablets due to the simplicity of the process, less handling difficulty from HPC tackiness as well as easier particle size targeting. Selecting the optimum ratio of plastic excipients and the particle size of starting materials can however be critical issues in this method.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Industrial Pharmacy Lab (Betz)
UniBasel Contributors:Betz, Gabriele
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Medknow
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:38

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