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Global structure-activity analysis in drug development illustrated for active Cu/Zn superoxide dismutase-mimics

Palivan, Cornelia G. and Balasubramanian, Vimalkumar and Goodman, Bernard. (2009) Global structure-activity analysis in drug development illustrated for active Cu/Zn superoxide dismutase-mimics. European Journal of Inorganic Chemistry, 2009 (31). pp. 4634-4639.

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Official URL: http://edoc.unibas.ch/dok/A5260316

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Abstract

The analysis of the spectroscopic and electrochemical properties of all reported classes of Cu/Zn superoxide dismutase mimics (SODm) makes it possible to distinguish the geometric specificity of highly active compounds. A linear relationship with EPR parameters characterises the geometry of the first coordination sphere around the metal, which favours catalytic activity. Combined with the appropriate redox potential values, the model of geometric conformation of highly active Cu/Zn SODm serves to streamline further synthetic efforts. This global analysis represents a new approach to treat all classes of compounds intended for a specific biological activity in order to obtain general features that could orient the process of drug discovery.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
UniBasel Contributors:Balasubramanian, Vimalkumar and Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1434-1948
e-ISSN:1099-0682
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Apr 2017 08:02
Deposited On:22 Mar 2012 14:08

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