Wollmer, M. A. and Streffer, J. R. and Tsolaki, M. and Grimaldi, L. M. E. and Lütjohann, D. and Thal, D. and von Bergmann, K. and Nitsch, R. M. and Hock, C. and Papassotiropoulos, A.. (2003) Genetic association of acyl-coenzyme A : cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. Molecular psychiatry, Vol. 8, H. 6. pp. 635-638.
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Official URL: http://edoc.unibas.ch/dok/A5257181
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Abstract
A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8).
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos) 07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Molecular Neuroscience (Papassotiropoulos) |
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| UniBasel Contributors: | Papassotiropoulos, Andreas |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 1359-4184 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 14 Sep 2012 06:39 |
| Deposited On: | 22 Mar 2012 13:17 |
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