Ward, Thomas R.. (2008) Artificial enzymes made to order : combination of computational design and directed evolution. Angewandte Chemie International Edition, 47 (41). pp. 7802-7803.
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Official URL: http://edoc.unibas.ch/dok/A5254499
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Abstract
Intelligent design: The combination of computational design and directed evolution has allowed the creation and optimization of an artificial enzyme starting from a catalytically inactive protein scaffold. In this approach, glutamate, tryptophane, and lysine residues were introduced into a TIM barrel fold to yield an artificial enzyme for the Kemp elimination that was fine-tuned by directed evolution (kcat/Km = 2590 M-1 S-1).
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 24 Apr 2017 12:39 |
| Deposited On: | 22 Mar 2012 14:15 |
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