Gumy, C. and Thurnbichler, C. and Aubry, E. M. and Balazs, Z. and Pfisterer, P. and Baumgartner, L. and Stuppner, H. and Odermatt, A. and Rollinger, J. M.. (2009) Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, Vol. 80, no.3. pp. 200-205.
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Official URL: http://edoc.unibas.ch/dok/A5251947
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Abstract
Elevated glucocorticoids are a key risk factor for metabolic diseases, and the glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) represents a promising therapeutic target. We measured the potential of six traditional antidiabetic medicinal plants extracts to inhibit 11beta-HSD1 activity and glucocorticoid receptor (GR) activation in transfected HEK-293 cells. Leave extracts of Eriobotrya japonica preferentially inhibited 11beta-HSD1 over 11beta-HSD2. Extracts of roasted but not native coffee beans preferentially inhibited 11beta-HSD1 over 11beta-HSD2, emphasizing the importance of sample preparation. Thus, natural compounds inhibiting 11beta-HSD1 may contribute to the antidiabetic effect of the investigated plant extracts.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt) |
|---|---|
| UniBasel Contributors: | Odermatt, Alex and Balazs, Zoltan |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier Science |
| ISSN: | 0367-326X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Last Modified: | 22 Mar 2012 14:22 |
| Deposited On: | 22 Mar 2012 13:31 |
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