Bühler, Marc and Steiner, Silvia and Mohn, Fabio and Paillusson, Alexandra and Mühlemann, Oliver. (2006) EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length. Nature structural & molecular biology, Vol. 13, no. 5. pp. 462-464.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A5251093
Downloads: Statistics Overview
Abstract
Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.
| Faculties and Departments: | 09 Associated Institutions > Friedrich Miescher Institut FMI |
|---|---|
| UniBasel Contributors: | Bühler, Marc |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publ. Group |
| ISSN: | 1545-9993 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 29 Jan 2016 07:46 |
| Deposited On: | 22 Mar 2012 13:30 |
Repository Staff Only: item control page