Jessen, H. J. and Barbaras, D. and Hamburger, M. and Gademann, K.. (2009) Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives. Organic Letters, 11 (15). pp. 3446-3449.
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Official URL: http://edoc.unibas.ch/dok/A5250907
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Abstract
An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling L-tyrosinol-amide as the pharmacophore.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger) |
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| UniBasel Contributors: | Hamburger, Matthias |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| e-ISSN: | 1523-7052 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 28 Nov 2017 10:45 |
| Deposited On: | 22 Mar 2012 13:32 |
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